THERAPEUTIC EXPERTISE

Solutions for Respiratory Research

People living with respiratory diseases experience a high symptom burden that severely impacts their quality of life. Digital health technologies (DHTs) capture patient-centered, objective outcome measures continuously and remotely, reducing participation burden and increasing the probability of trial success with improved measurement accuracy.

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Indications Where DHTs Have Been Included in Clinical Development

  • Chronic Obstructive Pulmonary Disease (COPD)
  • Asthma
  • Idiopathic Pulmonary Fibrosis (IPF)
  • Pulmonary Arterial Hypertension (PAH)
  • Cystic Fibrosis
  • Sleep Apnea
  • Chronic Cough

Selected Digital Endpoints in Respiratory

Physical Activity

  • Moderate to Vigorous Physical Activity (MVPA)
  • Non-Sedentary Time
  • Step Count
  • Real-World 6-Minute Peak Activity

Gait & Mobility

  • Gait Speed / Cadence
  • 6 Minute Walk Distance
  • Daily Total Activity Counts
  • Distance

Sleep

  • Total Sleep Time
  • Wake After Sleep Onset (WASO)
  • Sleep Onset Latency
  • Sleep Efficiency

Cardinal Symptoms

  • Cough Frequency
  • Cough Bouts

Vital Signs

  • Oxygen Saturation during Sleep
  • Heart Rate (HR)
  • Respiratory Rate (RR)
  • Blood Pressure
  • Skin Temperature
Physical Activity
  • Moderate to Vigorous Physical Activity (MVPA)
  • Non-Sedentary Time
  • Step Count
  • Real-World 6-Minute Peak Activity
Gait & Mobility
  • Gait Speed / Cadence
  • 6 Minute Walk Distance
  • Daily Total Activity Counts
  • Distance
Sleep
  • Total Sleep Time
  • Wake After Sleep Onset (WASO)
  • Sleep Onset Latency
  • Sleep Efficiency
Cardinal Symptoms
  • Cough Frequency
  • Cough Bouts
Vital Signs
  • Oxygen Saturation during Sleep
  • Heart Rate (HR)
  • Respiratory Rate (RR)
  • Blood Pressure
  • Skin Temperature

Respiratory Digital Endpoint Guide

To learn more about opportunities with wearable digital health technologies in respiratory disease clinical trials, download our full guide.

Download the Guide
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Continuous Cough Monitoring

Cough is a significant symptom in many respiratory diseases and is often associated with lower quality of life and disease progression. Accurately assessing cough is a challenge with traditional measures such as patient-reported outcomes and 24-hour monitoring solutions.

Our new digital health solution for cough monitoring leverages Hyfe’s validated cough detection algorithms and the FDA-cleared, multisensor ActiGraph LEAP for continuous, real-world, and privacy-first cough monitoring alongside industry-leading digital measures of sleep and physical activity. Achieve superior accuracy, user experience, and scalability for modern respiratory research.

Key Features and Benefits:

  • Obtain cough, sleep, and activity data using a single wrist-worn wearable
  • Privacy-preserving cough detection with AI-powered, validated algorithms
  • Long-term, continuous cough monitoring solution
  • Real-time data access
Download the Solution Sheet
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Functional Assessments

Respiratory diseases have a high burden on quality of life, significantly impacting patients’ physical functioning, mobility, and sleep. In-clinic performance-based outcomes (i.e., 6-Minute Walk Test) and clinician- and patient-reported outcomes miss important information due to their episodic and subjective nature.

Demonstrate meaningful patient-centric benefits and make informed, data-based decisions with continuous, quantitative, precise data of participant function collected with our state-of-the-art wearable digital health technology solution.

Key Features and Benefits:

  • FDA cleared, medical-grade wearables
  • Passive, remote data collection and transfer
  • Participant adherence monitoring
  • Simple technology deployments and end-to-end operational support
Read the Case Study

Patient-Focused Digital Measures Reports

Access our respiratory digital measure reports inspired by the FDA’s Patient-Focused Drug Development (PFDD) initiative, leveraging information from Voice of the Patient summaries to highlight how digital health technologies can help measure symptoms that are meaningful to patients.

Experience in Respiratory Trials

42
trials
5,696
participants
52
countries
1,974
sites