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Educational

Resources

Explore ActiGraph's educational resources to gain a deeper understanding of Digital Health Technologies in clinical trials.

Resources

The Importance of Patient-focused Drug Development

Clinical benefit is a positive effect on how the patient feels, functions, and survives. For study teams to demonstrate clinically meaningful effect(s) of a therapeutic intervention, it's critical to understand how a patient is impacted by a condition to define relevant concepts of interest and select appropriate measures for clinical trial endpoints.

Therapeutic Area Indication Most Significant Symptoms Reported by Patients Meaningful Aspects of Health Candidate Digital Measures Digital Measures Report
Neurology Parkinson's Disease
  • Motor Symptoms
  • Cognitive Dysfunction
  • Sleep Disturbances
  • Cardinal Symptoms
  • Sleep 
  • Bradykinesia Score
  • Dyskinesia Score
  • Percent Time Tremor
  • Wake after sleep onset
 View Report
Cardiology Hypertrophic Cardiomyopathy (HCM)
  • Shortness of Breath or Trouble Breathing
  • Exercise Intolerance
  • Lightheadedness, Dizziness, Fainting
  • Arrhythmias / Heart Palpitations
  • Physical Activity
  • Gait and Mobility
  • Vital Signs
  • Non-sedentary time 
  • Walking bouts 
  • Walking speed
  • Arrhythmia burden
 View Report
Dermatology Atopic Dermatitis (Eczema)
  • Itchiness
  • Red, Inflamed Skin
  • Pain
  • Sleep Disturbances
  • Scratch 
  • Sleep
  • Wake after sleep onset
  • Total scratch time
 View Report
Respirology Idiopathic Pulmonary Fibrosis (IPF)
  • Coughing
  • Shortness of Breath
  • Fatigue
  • Physical Activity
  • Cough
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Step count
  • Cough
 View Report
Respirology Obstructive Sleep Apnea (OSA)
  • Fatigue and Daytime Sleepiness
  • Unrefreshing Sleep
  • Cognitive Issues
  • Physical Activity
  • Sleep 
  • Vital Signs
  • Non-sedentary time 
  • Wake after sleep onset
  • Night time oxygen saturation
 View Report
Cardiology Pulmonary Arterial Hypertension (PAH)
  • Shortness of Breath
  • Fatigue
  • Physical Activity
  • Gait and Mobility
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Walking bouts 
  • Walking speed
 View Report
Dermatology Psoriasis
  • Itching
  • Flaking or Scaling Skin
  • Dry, Cracked Skin that may bleed
  • Stinging, Burning, and/or Pain
  • Scratch 
  • Sleep
  • Physical Activity
  • Wake after sleep onset
  • Total scratch time
  • Step count
  • Non-sedentary time
 View Report
Neurology Narcolepsy
  • Excessive Daytime Sleepiness
  • Cataplexy
  • Sleep Dysfunction
  • Cognitive Effects and Automatic Behaviors
  • Physical Activity
  • Sleep
  • Vital Signs
  • Non-sedentary time 
  • Wake after sleep onset
  • Daytime immobility bouts
 View Report
Respirology Asthma
  • Shortness of Breath or Trouble Breathing
  • Frequent Coughing
  • Chest Tightness
  • Mood changes
  • Physical Activity
  • Sleep
  • Cough
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Step count
  • Wake after sleep onset
  • Cough
 View Report
Rheumatology Osteoarthritis (OA)
  • Pain and Tenderness
  • Stiffness
  • Functional Limitations and Impaired Mobility
  • Fatigue and Sleep Disturbances
  • Physical Activity
  • Sleep
  • Gait and Mobility
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Step count
  • Walking bouts
  • Walking speed
  • Wake after sleep onset
 View Report
Oncology Cancer Cachexia
  • Muscle Weakness
  • Fatigue/Feelings of Tiredness
  • Loss of Appetite
  • Severe Weight Loss
  • Physical Activity
  • Gait and Mobility
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Walking bouts 
  • Walking speed
 View Report
Neurology Myotonic Dystrophy (DM)
  • Muscle Weakness and Myotonia
  • Fatigue
  • Pain
  • Heart Problems
  • Physical Activity
  • Gait and Mobility
  • Sleep
  • Vital Signs
  • Non-Sedentary Time
  • Step Count
  • Walking Bouts
  • Walking Speed / Cadence
  • Wrist 6 Minute Peak Activity
  • Specific Wrist Movement Metrics
  • Wake After Sleep Onset
  • Arrhythmia Burden
 View Report
Neurology Spinal Muscular Atrophy (SMA)
  • Fatigue
  • Muscle Weakness and Loss of Mobility
  • Breathing Difficulties
  • Physical Activity
  • Gait and Mobility
  • Non-Sedentary Time
  • Step Count
  • Walking Bouts 
  • Walking Speed
  • Wrist 6 Minute Peak Activity 
  • Specific Wrist Movement Metrics
 View Report
Neurology Kennedy’s Disease (KD) / Spinal and bulbar muscular atrophy (SBMA)
  • Muscle Weakness and Cramping
  • Fatigue
  • Breathing Difficulties
  • Balance Issues
  • Physical Activity
  • Gait and Mobility 
  • Non-Sedentary Time
  • Walking Bouts 
  • Walking Speed / Cadence
 View Report
Neurology Amyotrophic Lateral Sclerosis (ALS)
  • Muscle Weakness and Fatigue
  • Shortness of Breath
  • Difficulty Sleeping
  • Speech Problems
  • Physical Activity
  • Gait and Mobility 
  • Sleep 
  • Speech
  • 6 Minute Peak Activity
  • Walking Bouts 
  • Walking Speed / Cadence
  • Step Counts
  • Specific Wrist Movement Metrics
 View Report
Neurology Huntington's Disease
  • Cognitive Impairment
  • Chorea and other Motor Symptoms
  • Depression or Anxiety
  • Physical Activity
  • Gait and Mobility
  • Chorea
  • Sleep
  • Total Activity Counts
  • Walking Bouts
  • Walking Speed / Cadence
  • Step Counts
  • Wrist Activity Counts
  • Dyskinesia Score
 View Report
Neurology Sarcopenia
  • Muscle Loss, Muscle Weakness, Frailty
  • Balance Problems and Falling
  • Fatigue
  • Muscle Pain
  • Physical Activity
  • Gait and Mobility
  • Sleep 
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Walking bouts 
  • Walking speed
 View Report
Rheumatology Systemic Sclerosis
  • Painful cold sensitivity
  • Gastrointestinal symptoms
  • Chronic Fatigue
  • Contractures and Calcinosis of Digits
  • Physical Activity
  • Sleep 
  • Non-sedentary time 
  • Wake after sleep onset
 View Report
Rheumatology Inclusion Body Myositis (IBM)
  • Muscle Weakness and Atrophy
  • Dysphagia
  • Fatigue
  • Physical Activity
  • Sleep
  • Gait and Mobility
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Step count
  • Walking speed
  • Wake after sleep onset
 View Report
hematology Hemophilia
  • Joint Damage and Pain
  • Bleeding
  • Physical Activity
  • Gait and Mobility
  • Moderate-to-Vigorous Physical Activity (MVPA)
  • Non-Sedentary Time
  • Step Count
  • Walking Bouts
  • Walking Speed
 View Report
Metabolic and Endocrinology Nonalcoholic Steatohepatitis (NASH)
  • Fatigue / Low Energy
  • Abdominal Pain
  • Physical Activity
  • Gait and Mobility
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Walking bouts 

Coming Soon
Oncology Lung Cancer
  • Fatigue
  • Breathing Difficulties and Shortness of Breath
  • Chronic Pain
  • Persistent Cough
  • Physical Activity
  • Sleep
  • Cough
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Step Count
  • Wake After Sleep Onset
  • Cough Frequency
 View Report
Oncology Breast Cancer
  • Fatigue and weakness
  • Pain
  • Depression or Anxiety
  • Physical Activity
  • Sleep
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Step Count
  • Wake After Sleep Onset
 View Report
Oncology Low-Grade Serous Ovarian Cancer
  • Fatigue
  • Bone / Pelvic Pain
  • Depression or Anxiety
  • Physical Activity
  • Gait and Mobility
  • Sleep
  • Moderate-to-Vigorous Physical Activity
  • Non-Sedentary Time
  • Step Count
  • Walking Bouts
  • Wake After Sleep Onset
 View Report
Oncology Xerostomia
  • Eating Challenges
  • Fatigue and Sleep Disruption
  • Sleep
  • Cough
  • Total Sleep Time
  • Wake After Sleep Onset
  • Cough Frequency
 View Report
Oncology Reducing Cardiac Late Effects in Pediatric Cancer Survivors
  • Shortness of Breath
  • Exercise Intolerance
  • Fatigue
  • Physical Activity
  • Gait and Mobility
  • Vital Signs
  • Moderate-to-Vigorous Physical Activity (MVPA)
  • Non-Sedentary Time
  • Step Count
  • Walking Bouts
  • Arrhythmia Burden
 View Report

White Papers and eBooks

Explore how ActiGraph's Digital Health Technologies are reshaping healthcare. Discover the valuable insights of ActiGraph's subject matter experts through our collection of White Papers and eBooks, and revolutionize the ability to remotely obtain and analyze real-world data.

White Paper
Crossing the Chasm: Real-World Value Realized from DHTs in Clinical Trials

Here, we’ve collected 4 real-world examples of clinical trials that incorporated DHTs. We assess the aspect of clinic...

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White Paper
Maximize Your R&D Investment in DHTs Through the Collection and Retention of Raw Sensor Data

Sensor-based digital health technologies (DHTs) have revolutionized the ability to remotely obtain and analyze clinic...

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White Paper
What Does the New FDA DHT Guidance Mean? A Practical Guide for Sponsors

In December 2021, the FDA released its first guidance specific to the use of digital health technologies (DHTs).

Read More

View all ActiGraph white papers and eBooks   

Maximize Your R&D Investment in DHTs Through the Collection and Retention of Raw Sensor Data
June 26, 2022
Sensor-based digital health technologies (DHTs) have revolutionized the ability to remotely obtain and analyze clinically relevant information from clinical trial participants. Through ActiGraph’s 20 years of experience supporting clinical research, we’ve learned that a key factor of success when using DHTs for clinical ...
Download Now
What Does the New FDA DHT Guidance Mean? A Practical Guide for Sponsors
June 9, 2022
In December 2021, the FDA released its first guidance specific to the use of digital health technologies (DHTs). This marked an important milestone, signifying willingness from regulators to adopt new digital clinical measurements. In this ActiGraph white paper, we've synthesized the FDA's guidance into a practical, actionable ...
Download Now
Objective Scratch Assessments Using Digital Health Technologies (DHTs)
May 16, 2022
Scratching an itch can result in further problems such as inflammation and lesions that, in turn, cause more itch. Often leading to a vicious scratch-itch cycle, the compulsion to scratch negatively affects the quality of life of millions of people.
Download Now
Understanding Usability: Guidance for Gathering Complete, Unbiased Data from Wearables
April 21, 2022
Usability is critical to wearable-enabled clinical trials, which is why the FDA calls usability testing a “critical component” of deploying digital technologies. When approaching usability, multiple characteristics need to be taken into consideration for each stakeholder, starting with participants who interact directly with the device.
Download Now
How Actigraphy is Clearing Operational Barriers to Decentralized Trials
March 10, 2022
In this ActiGraph white paper, we cover the operational challenges of DCTs and how actigraphy is being used to clear those barriers.
Download Now
A Guide to Wearable-Enabled Digital Clinical Measures in Neuroscience eBook
February 4, 2022
Neurological diseases are inherently complex, and drug development in neurology is notoriously challenging. The imprecision of both disease diagnosis and symptom monitoring presents additional hurdles for clinical development.
Download Now
Reimagining Oncology Clinical Trials with Digital Biomarkers
December 6, 2021
Health metrics enabled by wearables are a huge untapped opportunity in oncology clinical trials. In this paper, we look at the perceived barriers to the adoption of wearables—and the major benefits that await sponsors that overcome them.
Download Now
Measuring Real-World Sleep with Actigraphy: Three ActiGraph Use Cases
December 2, 2021
In this white paper, we present three use cases for collecting actigraphy-derived sleep measures during an interventional clinical trial.
Download Now
Clinical Data Capture eBook
June 9, 2022
As the capabilities of wearable technologies continue to advance and the decentralization of clinical trials has become a mission-critical objective for many sponsor organizations, conventional methods of data collection must evolve to meet this changing industry landscape.
Download Now
How Future Proof Is Your Digital Biomarker Data? Considerations for maximizing the long-term value of wearable sensor data
March 8, 2021
When evaluating wearable motion-sensing technologies for clinical research, there are a myriad of factors to consider, including battery life, storage capacity, data access, validation, patient acceptance, privacy, and regulatory clearance, to name a few.
Download Now
Actigraphy Monitoring Wearables in Clinical Trials: Overcoming Barriers to Adoption & Strategies for Successful Technology Implementation
March 13, 2018
In this white paper, ActiGraph experts discuss several common perceived barriers to actigraphy adoption and identify strategies to help sponsors develop a successful technology implementation plan and navigate the common challenges that can derail any mHealth data collection initiative, including: Data quality and meaningful interpretation Adoption costs and uncertain ROI ...
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Scaling and Correcting Accelerometer Data Affected by 16CPAN03
November 8, 2016
In March of 2016, ActiGraph identified an issue that caused a data anomaly (raw data attenuation) on wGT3X-BT activity monitor units shipped between November 7, 2013 and March 24, 2014 which had collected data with firmware versions 1.4.0, 1.4.1, 1.5.0, 1.6.0 or 1.7.0. In order to minimize the impact on academic publications which rely on data from these units, ...
Download Now
ActiGraph White Paper: IMU Data
May 5, 2015
ActiGraph has recently released the ActiGraph GT9X Link, which contains an Inertial Measurement Unit (IMU). The IMU sensors and data output units of measure are listed in Table 1 below.
Download Now
ActiGraph White Paper: Accelerometer Technologies, Specifications, and Limitations
August 1, 2013
Technology advances and manufacturing efficiency improvements have drastically increased the options and flexibility available to users of accelerometer-based products. These advancements have led to confusion among activity monitor users, and many have been led to believe that device output normalization is an obvious and easy step. In truth, there are ...
Download Now
ActiGraph White Paper: Low Frequency Extension Filter
January 25, 2012
ActiGraph's new low frequency extension filter option now allows users to capture data previously unavailable. By adjusting filter criteria to allow more data to be retained in low activity and/or low frequency environments, elderly or other slow moving subjects can be studied. This filter significantly improves response to both ...
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ActiGraph White Paper: Actigraphy Sleep Scoring Algorithms
August 26, 2010
At present there are two algorithms that are primarily used to perform sleep scoring on actigraphy data captured by ActiGraph devices. These are the Cole-Kripke1 algorithm and the Sadeh2 algorithm.
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ActiGraph White Paper: Estimating Human Position with the ActiGraph GT3X Triaxial Activity Monitor
March 13, 2009
With the introduction of 3-axis accelerometers, it is now possible to expand beyond gross measurement of physical activity and classify activity types. The ActiGraph GT3X Triaxial Activity Monitor takes a first step in this direction with an inclinometer feature that indicates whether a subject is standing, sitting or lying ...
Download Now
ActiGraph White Paper: What is a Count?
May 19, 2008
ActiGraph routinely fields questions and inquiries regarding the definition of a ‘count’, the unit of measure for activity for ActiGraph’s monitors. Users are concerned about the ambiguity of this term and how it relates to the physical world. Although the origin of the term ‘count’ is unknown in its ...
Download Now
View all

Recent On-Demand Webinars

Watch previously recorded webinar discussions with industry leaders, who share their expertise in digital health technologies.

November 1, 2023
LEAP Into the Future of Patient-Centered Research: Introducing the Latest Innovation in Wearable Technology

Watch this exclusive webinar as we unveil the ActiGraph LEAP™, our latest innovation in wearable digital health techn...

Read More
August 29, 2023
Advancing Heart Failure Research with Digital Measures

This 1-hour webinar explores how sensor-based digital health technologies (DHTs) can be used to collect clinically me...

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April 1, 2023
Accelerating Rare Disease Drug Development with Wearable Digital Health Technologies

More than 90% of rare diseases do not have any treatment, representing a substantial unmet need for patients.

Read More

View all ActiGraph webinars   

Recent Webinars
Watch previously recorded webinar discussions with industry leaders, who share their expertise in digital health technologies.
All Webinars
LEAP into the Future of Patient-Centered Research: Introducing the Latest Innovation in Wearable Technology
November 1, 2023
View details
Advancing Heart Failure Research with Digital Measures
August 29, 2023
View details
Accelerating Rare Disease Drug Development with Wearable Digital Health Technologies
April 26, 2023
View details

ActiGraph News

Checkout the latest press releases, updates and videos.

digital clinical measures
ActiGraph Accelerates Clinical Trial Modernization with Transformational Acquisition of Biofourmis Life Science Business
PENSACOLA, FL, January 7, 2025 -ActiGraph, the global leader in wearable digital health technology for clinical research...
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digital clinical measures
ActiGraph and Hyfe Announce Availability of New Digital Health Tool for Cough Monitoring
PENSACOLA, FL, January 28, 2025 -ActiGraph, the global leader in wearable digital health technology for clinical researc...
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digital clinical measures
ActiGraph and Indivi Announce Partnership to Advance Precision Neuroscience Trials
PENSACOLA, FL, October 30, 2024 -ActiGraph, a leading provider of wearable technology and scientific services for clinic...
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View all ActiGraph news   

ActiGraph Blog

Check out the latest industry focused articles.

sleep
ActiGraph Chosen to Support Wearable Data Collection for NHANES 2027 Cohort
ActiGraph, the leading provider of wearable digital health solutions, is excited to share that we have been selected by ...
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oncology
The Pathway to a Digital Health Solution for Cytokine Release Syndrome Detection and Prediction
In this article, I’m excited to dive into the opportunities and challenges in the field of immunotherapy treatments, and...
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clinical research
Reflecting on a Year of Transformative Advancements in Digital Health
As we embark on another exciting year for the digital health landscape, I wanted to take a moment to reflect on the stri...
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View all ActiGraph blogs   

Upcoming Events

Engage with the ActiGraph team at one of our scheduled virtual presentations or in-person conferences.

ADPD 2025
CONFERENCE
ADPD 2025
April 1
 - 
5, 2025
April 1 - 5, 2025
Vienna, Austria
ActiGraph will be exhibiting at this event. Please contact meetings@theactigraph.com to schedule a meeting.
LEARN MORE
ATS 2025
CONFERENCE
ATS 2025
May 18
 - 
21, 2025
May 18 - 21, 2025
San Francisco, CA
ActiGraph will be exhibiting at this event. Please contact meetings@theactigraph.com to schedule a meeting.
LEARN MORE

View all ActiGraph events   

ActiGraph

Pioneering the Digital Transformation of Clinical Research™