Educational
Resources
Explore ActiGraph's educational resources to gain a deeper understanding of Digital Health Technologies in clinical trials.
The Importance of Patient-focused Drug Development
Clinical benefit is a positive effect on how the patient feels, functions, and survives. For study teams to demonstrate clinically meaningful effect(s) of a therapeutic intervention, it's critical to understand how a patient is impacted by a condition to define relevant concepts of interest and select appropriate measures for clinical trial endpoints.
| Therapeutic Area | Indication | Most Significant Symptoms Reported by Patients | Meaningful Aspects of Health | Candidate Digital Measures | Digital Measures Report |
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| Neurology | Parkinson's Disease |
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| Cardiology | Hypertrophic Cardiomyopathy (HCM) |
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| Dermatology | Atopic Dermatitis (Eczema) |
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| Respirology | Idiopathic Pulmonary Fibrosis (IPF) |
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| Respirology | Obstructive Sleep Apnea (OSA) |
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| Cardiology | Pulmonary Arterial Hypertension (PAH) |
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| Dermatology | Psoriasis |
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| Neurology | Narcolepsy |
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| Respirology | Asthma |
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| Rheumatology | Osteoarthritis (OA) |
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| Oncology | Cancer Cachexia |
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| Metabolic and Endocrinology | Nonalcoholic Steatohepatitis (NASH) |
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| Neurology | Myotonic Dystrophy (DM) |
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| Neurology | Sarcopenia |
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| Neurology | Spinal Muscular Atrophy (SMA) |
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| Neurology | Kennedy’s Disease (KD) / Spinal and bulbar muscular atrophy (SBMA) |
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| Neurology | Amyotrophic Lateral Sclerosis (ALS) |
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| Rheumatology | Systemic Sclerosis |
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| Rheumatology | Inclusion Body Myositis (IBM) |
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White Papers and eBooks
Explore how ActiGraph's Digital Health Technologies are reshaping healthcare. Discover the valuable insights of ActiGraph's subject matter experts through our collection of White Papers and eBooks, and revolutionize the ability to remotely obtain and analyze real-world data.
White Paper
Here, we’ve collected 4 real-world examples of clinical trials that incorporated DHTs. We assess the aspect of clinic...
White Paper
Sensor-based digital health technologies (DHTs) have revolutionized the ability to remotely obtain and analyze clinic...
White Paper
In December 2021, the FDA released its first guidance specific to the use of digital health technologies (DHTs).
eBook
Neurological diseases are inherently complex, and drug development in neurology is notoriously challenging.
White Paper
Scratching an itch can result in further problems such as inflammation and lesions that, in turn...
White Paper
Usability is critical to wearable-enabled clinical trials, which is why the FDA calls usability...
White Paper
In this ActiGraph white paper, we cover the operational challenges of DCTs and how actigraphy is being used to clear ...
Maximize Your R&D Investment in DHTs Through the Collection and Retention of Raw Sensor Data
June 26, 2022
Sensor-based digital health technologies (DHTs) have revolutionized the ability to remotely obtain and analyze clinically relevant information from clinical trial participants. Through ActiGraph’s 20 years of experience supporting clinical research, we’ve learned that a key factor of success when using DHTs for clinical ...
What Does the New FDA DHT Guidance Mean? A Practical Guide for Sponsors
June 9, 2022
In December 2021, the FDA released its first guidance specific to the use of digital health technologies (DHTs). This marked an important milestone, signifying willingness from regulators to adopt new digital clinical measurements. In this ActiGraph white paper, we've synthesized the FDA's guidance into a practical, actionable ...
Objective Scratch Assessments Using Digital Health Technologies (DHTs)
May 16, 2022
Scratching an itch can result in further problems such as inflammation and lesions that, in turn, cause more itch. Often leading to a vicious scratch-itch cycle, the compulsion to scratch negatively affects the quality of life of millions of people.
Understanding Usability: Guidance for Gathering Complete, Unbiased Data from Wearables
April 21, 2022
Usability is critical to wearable-enabled clinical trials, which is why the FDA calls usability testing a “critical component” of deploying digital technologies. When approaching usability, multiple characteristics need to be taken into consideration for each stakeholder, starting with participants who interact directly with the device.
How Actigraphy is Clearing Operational Barriers to Decentralized Trials
March 10, 2022
In this ActiGraph white paper, we cover the operational challenges of DCTs and how actigraphy is being used to clear those barriers.
A Guide to Wearable-Enabled Digital Clinical Measures in Neuroscience eBook
February 4, 2022
Neurological diseases are inherently complex, and drug development in neurology is notoriously challenging. The imprecision of both disease diagnosis and symptom monitoring presents additional hurdles for clinical development.
Reimagining Oncology Clinical Trials with Digital Biomarkers
December 6, 2021
Health metrics enabled by wearables are a huge untapped opportunity in oncology clinical trials. In this paper, we look at the perceived barriers to the adoption of wearables—and the major benefits that await sponsors that overcome them.
Measuring Real-World Sleep with Actigraphy: Three ActiGraph Use Cases
December 2, 2021
In this white paper, we present three use cases for collecting actigraphy-derived sleep measures during an interventional clinical trial.
Clinical Data Capture eBook
June 9, 2022
As the capabilities of wearable technologies continue to advance and the decentralization of clinical trials has become a mission-critical objective for many sponsor organizations, conventional methods of data collection must evolve to meet this changing industry landscape.
How Future Proof Is Your Digital Biomarker Data? Considerations for maximizing the long-term value of wearable sensor data
March 8, 2021
When evaluating wearable motion-sensing technologies for clinical research, there are a myriad of factors to consider, including battery life, storage capacity, data access, validation, patient acceptance, privacy, and regulatory clearance, to name a few.
Actigraphy Monitoring Wearables in Clinical Trials: Overcoming Barriers to Adoption & Strategies for Successful Technology Implementation
March 13, 2018
In this white paper, ActiGraph experts discuss several common perceived barriers to actigraphy adoption and identify strategies to help sponsors develop a successful technology implementation plan and navigate the common challenges that can derail any mHealth data collection initiative, including: Data quality and meaningful interpretation Adoption costs and uncertain ROI ...
Scaling and Correcting Accelerometer Data Affected by 16CPAN03
November 8, 2016
In March of 2016, ActiGraph identified an issue that caused a data anomaly (raw data attenuation) on wGT3X-BT activity monitor units shipped between November 7, 2013 and March 24, 2014 which had collected data with firmware versions 1.4.0, 1.4.1, 1.5.0, 1.6.0 or 1.7.0. In order to minimize the impact on academic publications which rely on data from these units, ...
ActiGraph White Paper: IMU Data
May 5, 2015
ActiGraph has recently released the ActiGraph GT9X Link, which contains an Inertial Measurement Unit (IMU). The IMU sensors and data output units of measure are listed in Table 1 below.
ActiGraph White Paper: Accelerometer Technologies, Specifications, and Limitations
August 1, 2013
Technology advances and manufacturing efficiency improvements have drastically increased the options and flexibility available to users of accelerometer-based products. These advancements have led to confusion among activity monitor users, and many have been led to believe that device output normalization is an obvious and easy step. In truth, there are ...
ActiGraph White Paper: Low Frequency Extension Filter
January 25, 2012
ActiGraph's new low frequency extension filter option now allows users to capture data previously unavailable. By adjusting filter criteria to allow more data to be retained in low activity and/or low frequency environments, elderly or other slow moving subjects can be studied. This filter significantly improves response to both ...
ActiGraph White Paper: Actigraphy Sleep Scoring Algorithms
August 26, 2010
At present there are two algorithms that are primarily used to perform sleep scoring on actigraphy data captured by ActiGraph devices. These are the Cole-Kripke1 algorithm and the Sadeh2 algorithm.
ActiGraph White Paper: Estimating Human Position with the ActiGraph GT3X Triaxial Activity Monitor
March 13, 2009
With the introduction of 3-axis accelerometers, it is now possible to expand beyond gross measurement of physical activity and classify activity types. The ActiGraph GT3X Triaxial Activity Monitor takes a first step in this direction with an inclinometer feature that indicates whether a subject is standing, sitting or lying ...
ActiGraph White Paper: What is a Count?
May 19, 2008
ActiGraph routinely fields questions and inquiries regarding the definition of a ‘count’, the unit of measure for activity for ActiGraph’s monitors. Users are concerned about the ambiguity of this term and how it relates to the physical world. Although the origin of the term ‘count’ is unknown in its ...
Recent On-Demand Webinars
Watch previously recorded webinar discussions with industry leaders, who share their expertise in digital health technologies.
November 1, 2023
Watch this exclusive webinar as we unveil the ActiGraph LEAP™, our latest innovation in wearable digital health techn...
August 29, 2023
This 1-hour webinar explores how sensor-based digital health technologies (DHTs) can be used to collect clinically me...
April 1, 2023
More than 90% of rare diseases do not have any treatment, representing a substantial unmet need for patients.
January 18, 2023
Digital transformation in healthcare and clinical research has been slower to progress than in other economic sectors...
Recent Webinars
Watch previously recorded webinar discussions with industry leaders, who share their expertise in digital health technologies.
LEAP into the Future of Patient-Centered Research: Introducing the Latest Innovation in Wearable Technology
November 1, 2023
Advancing Heart Failure Research with Digital Measures
August 29, 2023
Accelerating Rare Disease Drug Development with Wearable Digital Health Technologies
April 26, 2023
ActiGraph News
Checkout the latest press releases, updates and videos.
PENSACOLA, FL, June 12, 2024 – ActiGraph, the leading provider of wearable digital health technology (DHT) solutions for...
PENSACOLA, FL, February 20, 2024 – ActiGraph and Cambridge Cognition, leading providers of wearable digital health techn...
PENSACOLA, FL, February 9, 2024 – ActiGraph, a leading provider of wearable technology and scientific services for acade...
Collaboration will generate evidence to contribute to FDA qualification of a patient-centered, accelerometer-based clini...
PENSACOLA, FL, November 20, 2023 - ActiGraph, a leader in wearable digital health technology and digital health sciences...
PENSACOLA, FL, November 13, 2023 - ActiGraph, a leader in wearable digital health technology and digital health sciences...
ActiGraph Blog
Check out the latest industry focused articles.
Wearable, sensor-based digital health technologies (DHTs) can help biotech and pharma teams accelerate their clinical de...
Clinical development is a challenging task. Clinical development in Parkinson’s disease (PD) faces additional challenges...
Artificial Intelligence (AI) has recently become a household term, with its influence permeating many aspects of life, f...
When it comes to incorporating new technology into drug development and clinical practice, the best place to start is wi...
Innovation is exciting, but it can also come with challenges; innovation in the life sciences field, particularly clinic...
Multiple Sclerosis (MS) is a chronic disease affecting the central nervous system, in which individuals' immune systems ...
Upcoming Events
Engage with the ActiGraph team at one of our scheduled virtual presentations or in-person conferences.
CONFERENCE
Clinical Trial Innovation Summit
October 22, 2024
October 22, 2024
San Francisco, CA
ActiGraph representatives will be attending this event. Please contact meetings@theactigraph.com to schedule a meeting.
CONFERENCE
Obesity Week
November 3, 2024
November 3-6, 2024
San Antonio, TX
ActiGraph representatives will be attending this event. Please contact meetings@theactigraph.com to schedule a meeting.
CONFERENCE
Medidata NEXT
November 13, 2024
November 13-14, 2024
New York, NY
ActiGraph representatives will be attending this event. Please contact meetings@theactigraph.com to schedule a meeting.
