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THERAPEUTIC EXPERTISE

Solutions for Neurology Research 

Neurological diseases are inherently complex, manifesting a variety of motor and non-motor symptoms.  This complexity creates significant clinical development challenges, with neurology trial failure rates among the highest in the industry. Digital measures provide frequent, objective, and precise measures of how people with neurological conditions function in the real-world, addressing the limitations of current assessments, providing a powerful tool to better understand treatment efficacy in neurology trials.

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Person with Movement Disorder

Indications Where DHTs Have Been Included in Clinical Development

Selected Digital Endpoints in Neurology

Sleep

  • Total Sleep Time
  • Wake After Sleep Onset
  • Sleep Latency
  • Sleep Efficiency
  • Circadian Rhythms
  • Sleep Architecture

Physical Activity

  • Moderate-to-Vigorous Physical Activity (MVPA)
  • Non-Sedentary Time
  • Step Count

Gait & Mobility

  • Walking speed / Walking Bouts
  • Real-world 6-minute Walk Distance
  • Upper Limb Mobility Measures

Vital Signs

  • Heart Rate Variability
  • Oxygen Saturation (SpO2) during Sleep

Cardinal Symptoms

  • Bradykinesia Score
  • Dyskinesia Score
  • Percent Time Tremor
Sleep
  • Total Sleep Time
  • Wake After Sleep Onset
  • Sleep Latency
  • Sleep Efficiency
  • Circadian Rhythms
  • Sleep Architecture
Physical Activity
  • Moderate-to-Vigorous Physical Activity (MVPA)
  • Non-Sedentary Time
  • Step Count
Gait & Mobility
  • Walking speed / Walking Bouts
  • Real-world 6-minute Walk Distance
  • Upper Limb Mobility Measures
Vital Signs
  • Heart Rate Variability
  • Oxygen Saturation (SpO2) during Sleep
Cardinal Symptoms
  • Bradykinesia Score
  • Dyskinesia Score
  • Percent Time Tremor

Digital Endpoint Guides

To learn more about opportunities with wearable digital health technologies in specific areas of neurology drug development, review our Digital Endpoint Guide collection.

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Person on a Wheelchair

Functional Assessments

Digital measures have the potential to transform and accelerate clinical development in neurology, one of the most active and notoriously challenging areas of research. Wearable-derived digital endpoints can be used to quantify motor symptoms, assess disease progression and severity, and provide insights on the quality of life across a variety of neurological.

High-frequency data collection with DHTs provides more sensitive outcome measures to inform decision making and provide unique insights in early phase clinical trials, and quantifiable evidence of treatment benefits in late-phase trials.

Learn how ActiGraph can partner with you to advance treatment options for patients through high-quality data generation, fit-for-purpose algorithms, and a systematic research framework following regulatory and industry standards.

Key Features and Benefits:

  • FDA cleared, medical-grade wearables
  • Passive, remote data collection and transfer
  • Advanced participant adherence monitoring
  • Simple technology deployments and end-to-end operational support
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Person with Sleep Disorder

Sleep Measures and Sleep Disorders

Digital measures enable efficient, accurate, and meaningful evidence generation in sleep disorders, and measure key aspects of quality of life in many chronic conditions where sleep is disrupted. Wearable DHTs can detect unique sleep patterns associated with sleep disorders and sleep changes associated with treatment interventions, providing quantifiable measures of otherwise difficult to obtain insights into sleep behavior.

Wearable-based sleep measures provide new opportunities to improve the accuracy and detail of sleep assessments with multisensor wearables, and offer a scientifically validated and scalable solution for researchers to incorporate patient-centric sleep assessments into clinical trials.

Key Features and Benefits:

  • Long-term, objective and ecologically valid data collection
  • Digital measures of sleep architecture (REM/Non-REM/Light/Deep)
  • Low-burden, scalable solution with passive, remote data collection
View Measures

Patient-Focused Digital Measures Reports

Access our neurology digital measure reports inspired by the FDA’s Patient-Focused Drug Development (PFDD) initiative, leveraging information from Voice of the Patient summaries to highlight how digital health technologies can help measure symptoms that are meaningful to patients.

Experience in Neurology Trials

62
trials
1,517
sites
44
countries
4,751
participants