Patient-Focused Digital Measures Library

Patient-Focused Digital Measure Reports

This library is inspired by the FDA's Patient-Focused Drug Development (PFDD) initiative's goal of better incorporating the patient's voice in drug development and evaluation, and leverages information from their comprehensive collection of Voice of the Patient Reports.

For each indication listed, we aim to relate the most significant symptoms described by patients to meaningful aspects of health that can be assessed using digital measures, highlighting opportunities for researchers to use data from medical-grade wearable DHTs to support patient-centric drug development. This information is summarized in the table below, and more details are provided in the indication-specific reports.

Read more about the inspiration for the library in this blog.

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Hypertrophic Cardiomyopathy (HCM)	Shortness of Breath or Trouble Breathing Exercise Intolerance Lightheadedness, Dizziness, Fainting Arrhythmias / Heart Palpitations	Physical Activity Gait and Mobility Vital Signs	Non-sedentary time Walking bouts Walking speed Arrhythmia burden	View Report
Pulmonary Arterial Hypertension (PAH)	Shortness of Breath Fatigue	Physical Activity Gait and Mobility	Moderate-to-vigorous physical activity Non-sedentary time Walking bouts Walking speed	View Report

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Atopic Dermatitis (Eczema)	Itchiness Red, Inflamed Skin Pain Sleep Disturbances	Scratch Sleep	Wake after sleep onset Total scratch time	View Report
Psoriasis	Itching Flaking or Scaling Skin Dry, Cracked Skin that may bleed Stinging, Burning, and/or Pain	Scratch Sleep Physical Activity	Wake after sleep onset Total scratch time Step count Non-sedentary time	View Report

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Hemophilia	Joint Damage and Pain Bleeding	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity (MVPA) Non-Sedentary Time Step Count Walking Bouts Walking Speed	View Report

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Parkinson's Disease	Motor Symptoms Cognitive Dysfunction Sleep Disturbances	Cardinal Symptoms Sleep	Bradykinesia Score Dyskinesia Score Percent Time Tremor Wake after sleep onset	View Report
Narcolepsy	Excessive Daytime Sleepiness Cataplexy Sleep Dysfunction Cognitive Effects and Automatic Behaviors	Physical Activity Sleep Vital Signs	Non-sedentary time Wake after sleep onset Daytime immobility bouts	View Report
Myotonic Dystrophy (DM)	Muscle Weakness and Myotonia Fatigue Pain Heart Problems	Physical Activity Gait and Mobility Sleep Vital Signs	Non-Sedentary Time Step Count Walking Bouts Walking Speed / Cadence Wrist 6 Minute Peak Activity Specific Wrist Movement Metrics Wake After Sleep Onset Arrhythmia Burden	View Report
Spinal Muscular Atrophy (SMA)	Fatigue Muscle Weakness and Loss of Mobility Breathing Difficulties	Physical Activity Gait and Mobility	Non-Sedentary Time Step Count Walking Bouts Walking Speed Wrist 6 Minute Peak Activity Specific Wrist Movement Metrics	View Report
Kennedy’s Disease (KD) / Spinal and bulbar muscular atrophy (SBMA)	Muscle Weakness and Cramping Fatigue Breathing Difficulties Balance Issues	Physical Activity Gait and Mobility	Non-Sedentary Time Walking Bouts Walking Speed / Cadence	View Report
Amyotrophic Lateral Sclerosis (ALS)	Muscle Weakness and Fatigue Shortness of Breath Difficulty Sleeping Speech Problems	Physical Activity Gait and Mobility Sleep Speech	6 Minute Peak Activity Walking Bouts Walking Speed / Cadence Step Counts Specific Wrist Movement Metrics	View Report
Huntington's Disease	Cognitive Impairment Chorea and other Motor Symptoms Depression or Anxiety	Physical Activity Gait and Mobility Chorea Sleep	Total Activity Counts Walking Bouts Walking Speed / Cadence Step Counts Wrist Activity Counts Dyskinesia Score	View Report
Sarcopenia	Muscle Loss, Muscle Weakness, Frailty Balance Problems and Falling Fatigue Muscle Pain	Physical Activity Gait and Mobility Sleep	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts Walking speed	View Report

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Cancer Cachexia	Muscle Weakness Fatigue/Feelings of Tiredness Loss of Appetite Severe Weight Loss	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts Walking speed	View Report

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Idiopathic Pulmonary Fibrosis (IPF)	Coughing Shortness of Breath Fatigue	Physical Activity Cough	Moderate-to-vigorous physical activity Non-sedentary time Step count Cough	View Report
Obstructive Sleep Apnea (OSA)	Fatigue and Daytime Sleepiness Unrefreshing Sleep Cognitive Issues	Physical Activity Sleep Vital Signs	Non-sedentary time Wake after sleep onset Night time oxygen saturation	View Report
Asthma	Shortness of Breath or Trouble Breathing Frequent Coughing Chest Tightness Mood changes	Physical Activity Sleep Cough	Moderate-to-vigorous physical activity Non-sedentary time Step count Wake after sleep onset Cough	View Report

Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Osteoarthritis (OA)	Pain and Tenderness Stiffness Functional Limitations and Impaired Mobility Fatigue and Sleep Disturbances	Physical Activity Sleep Gait and Mobility	Moderate-to-vigorous physical activity Non-sedentary time Step count Walking bouts Walking speed Wake after sleep onset	View Report
Systemic Sclerosis	Painful cold sensitivity Gastrointestinal symptoms Chronic Fatigue Contractures and Calcinosis of Digits	Physical Activity Sleep	Non-sedentary time Wake after sleep onset	View Report
Inclusion Body Myositis (IBM)	Muscle Weakness and Atrophy Dysphagia Fatigue	Physical Activity Sleep Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Step count Walking speed Wake after sleep onset	View Report

Christmas

Patient-Focused Digital Measures Library