Patient-Focused Digital Measures Library

Patient-Focused Digital Measure Reports

This library is inspired by the FDA's Patient-Focused Drug Development (PFDD) initiative's goal of better incorporating the patient's voice in drug development and evaluation, and leverages information from their comprehensive collection of Voice of the Patient Reports.

For each indication listed, we aim to relate the most significant symptoms described by patients to meaningful aspects of health that can be assessed using digital measures, highlighting opportunities for researchers to use data from medical-grade wearable DHTs to support patient-centric drug development. This information is summarized in the table below, and more details are provided in the indication-specific reports.

Read more about the inspiration for the library in this blog.

Therapeutic Area	Indication	Most Significant Symptoms Reported by Patients	Meaningful Aspects of Health	Candidate Digital Measures	Digital Measures Report
Neurology	Parkinson's Disease	Motor Symptoms Cognitive Dysfunction Sleep Disturbances	Cardinal Symptoms Sleep	Bradykinesia Score Dyskinesia Score Percent Time Tremor Wake after sleep onset	View Report
Cardiology	Hypertrophic Cardiomyopathy (HCM)	Shortness of Breath or Trouble Breathing Exercise Intolerance Lightheadedness, Dizziness, Fainting Arrhythmias / Heart Palpitations	Physical Activity Gait and Mobility Vital Signs	Non-sedentary time Walking bouts Walking speed Arrhythmia burden	View Report
Dermatology	Atopic Dermatitis (Eczema)	Itchiness Red, Inflamed Skin Pain Sleep Disturbances	Scratch Sleep	Wake after sleep onset Total scratch time	View Report
Respirology	Idiopathic Pulmonary Fibrosis (IPF)	Coughing Shortness of Breath Fatigue	Physical Activity Cough	Moderate-to-vigorous physical activity Non-sedentary time Step count Cough	View Report
Respirology	Obstructive Sleep Apnea (OSA)	Fatigue and Daytime Sleepiness Unrefreshing Sleep Cognitive Issues	Physical Activity Sleep Vital Signs	Non-sedentary time Wake after sleep onset Night time oxygen saturation	View Report
Cardiology	Pulmonary Arterial Hypertension (PAH)	Shortness of Breath Fatigue	Physical Activity Gait and Mobility	Moderate-to-vigorous physical activity Non-sedentary time Walking bouts Walking speed	View Report
Dermatology	Psoriasis	Itching Flaking or Scaling Skin Dry, Cracked Skin that may bleed Stinging, Burning, and/or Pain	Scratch Sleep Physical Activity	Wake after sleep onset Total scratch time Step count Non-sedentary time	View Report
Neurology	Narcolepsy	Excessive Daytime Sleepiness Cataplexy Sleep Dysfunction Cognitive Effects and Automatic Behaviors	Physical Activity Sleep Vital Signs	Non-sedentary time Wake after sleep onset Daytime immobility bouts	View Report
Respirology	Asthma	Shortness of Breath or Trouble Breathing Frequent Coughing Chest Tightness Mood changes	Physical Activity Sleep Cough	Moderate-to-vigorous physical activity Non-sedentary time Step count Wake after sleep onset Cough	View Report
Rheumatology	Osteoarthritis (OA)	Pain and Tenderness Stiffness Functional Limitations and Impaired Mobility Fatigue and Sleep Disturbances	Physical Activity Sleep Gait and Mobility	Moderate-to-vigorous physical activity Non-sedentary time Step count Walking bouts Walking speed Wake after sleep onset	View Report
Oncology	Cancer Cachexia	Muscle Weakness Fatigue/Feelings of Tiredness Loss of Appetite Severe Weight Loss	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts Walking speed	View Report
Neurology	Myotonic Dystrophy (DM)	Muscle Weakness and Myotonia Fatigue Pain Heart Problems	Physical Activity Gait and Mobility Sleep Vital Signs	Non-Sedentary Time Step Count Walking Bouts Walking Speed / Cadence Wrist 6 Minute Peak Activity Specific Wrist Movement Metrics Wake After Sleep Onset Arrhythmia Burden	View Report
Neurology	Spinal Muscular Atrophy (SMA)	Fatigue Muscle Weakness and Loss of Mobility Breathing Difficulties	Physical Activity Gait and Mobility	Non-Sedentary Time Step Count Walking Bouts Walking Speed Wrist 6 Minute Peak Activity Specific Wrist Movement Metrics	View Report
Neurology	Kennedy’s Disease (KD) / Spinal and bulbar muscular atrophy (SBMA)	Muscle Weakness and Cramping Fatigue Breathing Difficulties Balance Issues	Physical Activity Gait and Mobility	Non-Sedentary Time Walking Bouts Walking Speed / Cadence	View Report
Neurology	Amyotrophic Lateral Sclerosis (ALS)	Muscle Weakness and Fatigue Shortness of Breath Difficulty Sleeping Speech Problems	Physical Activity Gait and Mobility Sleep Speech	6 Minute Peak Activity Walking Bouts Walking Speed / Cadence Step Counts Specific Wrist Movement Metrics	View Report
Neurology	Huntington's Disease	Cognitive Impairment Chorea and other Motor Symptoms Depression or Anxiety	Physical Activity Gait and Mobility Chorea Sleep	Total Activity Counts Walking Bouts Walking Speed / Cadence Step Counts Wrist Activity Counts Dyskinesia Score	View Report
Metabolic and Endocrinology	Nonalcoholic Steatohepatitis (NASH)	Fatigue / Low Energy Abdominal Pain	Physical Activity Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts	Coming Soon
Neurology	Sarcopenia	Muscle Loss, Muscle Weakness, Frailty Balance Problems and Falling Fatigue Muscle Pain	Physical Activity Gait and Mobility Sleep	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Walking bouts Walking speed	Coming Soon
Rheumatology	Systemic Sclerosis	Painful cold sensitivity Gastrointestinal symptoms Chronic Fatigue Contractures and Calcinosis of Digits	Physical Activity Sleep	Non-sedentary time Wake after sleep onset	Coming Soon
Rheumatology	Inclusion Body Myositis (IBM)	Muscle Weakness and Atrophy Dysphagia Fatigue	Physical Activity Sleep Gait and Mobility	Moderate-to-Vigorous Physical Activity Non-Sedentary Time Step count Walking speed Wake after sleep onset	Coming Soon

Patient-Focused Digital Measures Library

Patient-Focused Digital Measure Reports

Patient-Focused Digital Measure Reports

Digital Endpoint Guides

Voice of the Patient

Related Measures

Digital Endpoint Guides

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Patient-Focused Digital Measures Library

Patient-Focused Digital Measure Reports

Patient-Focused Digital Measure Reports

Digital Endpoint Guides

Voice of the Patient

Related Measures

Digital Endpoint Guides

Schedule a Meeting with a Member of our Team

Pioneering the Digital Transformation of Clinical Research™

Connect with us

Pioneering the Digital Transformation of Clinical Research^™