Patient-Focused Digital Measures Library

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Patient-Focused Digital Measure Reports

This library is inspired by the FDA's Patient-Focused Drug Development (PFDD) initiative's goal of better incorporating the patient's voice in drug development and evaluation, and leverages information from their comprehensive collection of Voice of the Patient Reports.

Patient-Focused Digital Measure Reports

This library is inspired by the FDA's Patient-Focused Drug Development (PFDD) initiative's goal of better incorporating the patient's voice in drug development and evaluation, and leverages information from their comprehensive collection of Voice of the Patient Reports.

For each indication listed, we aim to relate the most significant symptoms described by patients to meaningful aspects of health that can be assessed using digital measures, highlighting opportunities for researchers to use data from medical-grade wearable DHTs to support patient-centric drug development. This information is summarized in the table below, and more details are provided in the indication-specific reports.

Read more about the inspiration for the library in this blog.

Therapeutic Area Indication Most Significant Symptoms Reported by Patients Meaningful Aspects of Health Candidate Digital Measures Digital Measures Report
Neurology Parkinson's Disease
  • Motor Symptoms
  • Cognitive Dysfunction
  • Sleep Disturbances
  • Cardinal Symptoms
  • Sleep 
  • Bradykinesia Score
  • Dyskinesia Score
  • Percent Time Tremor
  • Wake after sleep onset
 View Report
Cardiology Hypertrophic Cardiomyopathy (HCM)
  • Shortness of Breath or Trouble Breathing
  • Exercise Intolerance
  • Lightheadedness, Dizziness, Fainting
  • Arrhythmias / Heart Palpitations
  • Physical Activity
  • Mobility
  • Vital Signs
  • Non-sedentary time 
  • Walking bouts 
  • Walking speed
  • Arrhythmia burden
 View Report
Dermatology Atopic Dermatitis (Eczema)
  • Itchiness
  • Red, Inflamed Skin
  • Pain
  • Sleep Disturbances
  • Scratch 
  • Sleep
  • Wake after sleep onset
  • Total scratch time
 View Report
Respirology Idiopathic Pulmonary Fibrosis (IPF)
  • Coughing
  • Shortness of Breath
  • Fatigue
  • Physical Activity
  • Cough
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Step count
  • Cough
 View Report
Respirology Obstructive Sleep Apnea (OSA)
  • Fatigue and Daytime Sleepiness
  • Unrefreshing Sleep
  • Cognitive Issues
  • Physical Activity
  • Sleep 
  • Vital Signs
  • Non-sedentary time 
  • Wake after sleep onset
  • Night time oxygen saturation
 View Report
Cardiology Pulmonary Arterial Hypertension (PAH)
  • Shortness of Breath
  • Fatigue
  • Physical Activity
  • Mobility
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Walking bouts 
  • Walking speed

Coming Soon
Dermatology Psoriasis
  • Itching
  • Flaking or Scaling Skin
  • Dry, Cracked Skin that may bleed
  • Stinging, Burning, and/or Pain
  • Scratch 
  • Sleep
  • Physical Activity
  • Wake after sleep onset
  • Total scratch time
  • Step count
  • Non-sedentary time

Coming Soon
Metabolic and Endocrinology Nonalcoholic Steatohepatitis (NASH)
  • Fatigue / Low Energy
  • Abdominal Pain
  • Physical Activity
  • Mobility
  • Activity profile index
  • Walking bouts 

Coming Soon
Neurology Myotonic Dystrophy (DM)
  • Muscle Weakness and Myotonia
  • Fatigue
  • Pain
  • Heart Problems
  • Physical Activity
  • Sleep
  • Gait and Mobility
  • Vital Signs
  • Activity profile index
  • Wake after sleep onset
  • Walking speed
  • A-fib

Coming Soon
Neurology Sarcopenia
  • Muscle Loss, Muscle Weakness, Frailty
  • Balance Problems and Falling
  • Fatigue
  • Muscle Pain
  • Physical Activity
  • Mobility
  • Sleep 
  • Activity profile index
  • Walking bouts 
  • Walking speed

Coming Soon
Neurology Spinal Muscular Atrophy (SMA)
  • Fatigue
  • Muscle Weakness and Loss of Mobility
  • Breathing Difficulties
  • Physical Activity
  • Mobility 
  • Upper Limb Function
  • Activity profile index
  • Walking bouts 
  • Walking speed
  • Upper limb movements

Coming Soon
Neurology Kennedy’s Disease (KD) / Spinal and bulbar muscular atrophy (SBMA)
  • Muscle Weakness and Cramping
  • Fatigue
  • Breathing Difficulties
  • Mobility Issues
  • Physical Activity
  • Mobility 
  • Activity profile index
  • Walking bouts 
  • Walking speed

Coming Soon
Neurology Narcolepsy
  • Excessive Daytime Sleepiness
  • Cataplexy
  • Sleep Dysfunction
  • Cognitive Effects and Automatic Behaviors
  • Physical Activity
  • Sleep
  • Vital Signs
  • Non-sedentary time 
  • Wake after sleep onset
  • Daytime immobility bouts

Coming Soon
Neurology Amyotrophic Lateral Sclerosis (ALS)
  • Muscle Weakness and Fatigue
  • Speech Problems
  • Shortness of Breath
  • Difficulty Sleeping
  • Physical Activity
  • Mobility 
  • Sleep 
  • Speech
  • Step count
  • Walking bouts 
  • Walking speed
  • Upper limb movements

Coming Soon
Respirology Asthma
  • Shortness of Breath or Trouble Breathing
  • Frequent Coughing
  • Chest Tightness
  • Mood changes
  • Physical Activity
  • Sleep
  • Cough
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Step count
  • Wake after sleep onset
  • Cough

Coming Soon
Rheumatology Systemic Sclerosis
  • Painful cold sensitivity
  • Gastrointestinal symptoms
  • Chronic Fatigue
  • Contractures and Calcinosis of Digits
  • Physical Activity
  • Sleep 
  • Non-sedentary time 
  • Wake after sleep onset

Coming Soon
Rheumatology Osteoarthritis (OA)
  • Pain and Tenderness
  • Stiffness
  • Functional Limitations and Impaired Mobility
  • Fatigue and Sleep Disturbances
  • Physical Activity
  • Sleep
  • Gait and Mobility
  • Moderate-to-vigorous physical activity
  • Non-sedentary time
  • Step count
  • Walking bouts
  • Walking speed
  • Wake after sleep onset

Coming Soon
Rheumatology Inclusion Body Myositis (IBM)
  • Muscle Weakness and Atrophy
  • Dysphagia
  • Fatigue
  • Physical Activity
  • Sleep
  • Gait and Mobility
  • Activity profile index
  • Step count
  • Walking speed
  • Wake after sleep onset

Coming Soon

For each indication listed, we aim to relate the most significant symptoms described by patients to meaningful aspects of health that can be assessed using digital measures, highlighting opportunities for researchers to use data from medical-grade wearable DHTs to support patient-centric drug development. This information is summarized in the table above, and more details are provided in the digital measures report.

Read more about the inspiration for the library in this blog.

Digital Endpoint Guides

Access our Digital Endpoint Guides for more information about how the use of digital endpoints can advance clinical research in specific therapeutic areas.

Voice of the Patient

Voice of the Patient

Based on Voice of the Patient meeting reports from the FDA PFDD initiative, we summarize the most significant symptoms reported by patients.

Related Measures

Related Measures

We outline the related measures that sensor-based wearable DHTs could help clinical researchers capture and relate them to indication-specific symptoms.

Digital Endpoint Guides

Digital Endpoint Guides

Links to therapeutic area specific Digital Endpoint Guides can provide further information about developing digital endpoints for clinical research.

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Schedule a meeting with a member of our team to discuss which patient-focused digital measures are right for your trial.

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