Research Study Abstract

Quantification of irregular circadian cycles using time-series methods

  • Published on April 10, 2019

The original focus of the field of chronobiology was to demonstrate that most – if not all – biological parameters are modulated in a regular way by the periodic alternation of day and night, called circadian cycles. Recently, it has become clear that adverse conditions such as ageing and/or disease induce a reduced or more irregular modulation, such that it has become of interest to quantify these irregularities as a proxy to understand underlying pathology. In the present contribution, we explore how recently developed time-series decomposition techniques such as SSA, EMD, EEMD and CEEMDAN may be applied to chronobiology to describe irregularities in circadian cycles.


  • Lorena Marisol García-Iglesias
  • Ana Leonor Rivera
  • Juan Claudio Toledo-Roy
  • Ruben Fossion


  • 1

    Instituto de Ciencias Nucleares, Universidad Autónoma de México

  • 2

    Universidad Autónoma del Estado de Morelos

  • 3

    Centro de Ciencias de la Complejidad (C3), Universidad Nacional Autónoma de México


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