Research Database

Study protocol and rationale of the “Cogni-action project” a cross-sectional and randomized controlled trial about physical activity, brain health, cognition, and educational achievement in schoolchildren

  • Published on July 26, 2019

Background Education and health are crucial topics for public policies as both largely determine the future wellbeing of the society. Currently, several studies recognize that physical activity (PA) benefits brain health in children. However, most of these studies have not been carried out in developing countries or lack the transference ...


Efficacy of Polygonatum sibiricum on Mild Insomnia: A Randomized Placebo-Controlled Trial

  • Published on July 25, 2019

Abstract Polygonatum sibiricum (PS) rhizome, which contains glyceryl-1-monolinoleate as its primary active component, has been shown to improve insomnia in animal models. Based on these findings, we aimed to investigate the safety and efficacy of PS rhizome extract in improving sleep quality in individuals with mild insomnia. Eighty individuals ...



Community, household, and individual correlates of sleep behaviors in Guyanese female youth

  • Published on July 9, 2019

Objectives Chronic sleep loss among youth is a worldwide health problem. Since research on its predictors is often limited to high‐income countries, it is unclear if these findings are generalizable to all populations. To address this gap from an ecological perspective, we evaluated the associations between adolescents' sleep behaviors ...


The cross‐sectional and prospective associations between sleep characteristics and adiposity in toddlers: Results from the GET UP! Study

  • Published on July 3, 2019

Background The associations between sleep characteristics and adiposity in children under three years are not fully understood yet. Objective The objective of the study is to examine the cross‐sectional and prospective associations between sleep characteristics and adiposity in toddlers over a 12‐month period. Methods Participants were 202 toddlers from the ...


The serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the sleep-promoting effects of tryptophan: A randomized placebo-controlled crossover study

  • Published on June 25, 2019

Background The low-expressive short (S) allele of a functional polymorphism (5-HTTLPR) within the serotonin (5-hydroxytriptamine; 5-HT) transporter gene (SLC6A4) has been associated with a reduced functioning of the brain 5-HT system relative to the long (L) allele. As a consequence, the S-allele is found to predispose individuals to a ...



Actigraphic detection of periodic limb movements: development and validation of a potential device-independent algorithm. A proof of concept study

  • Published on June 13, 2019

Study Objectives We propose a unique device-independent approach to analyze long-term actigraphy signals that can accurately quantify the severity of periodic limb movements in sleep (PLMS). Methods We analyzed 6–8 hr of bilateral ankle actigraphy data for 166 consecutively consenting patients who simultaneously underwent routine clinical polysomnography. Using the proposed algorithm, we ...


A preliminary study of a composite sleep health score: associations with psychological distress, body mass index, and physical functioning in a low-income African American community

  • Published on June 14, 2019

Objectives Although multiple individual sleep measures (eg, sleep duration, satisfaction) have been linked to a wide range of physical and mental health conditions, scant research has examined how individual sleep dimensions may act independently or additively to influence health. The current study investigates associations of 5 sleep dimensions (duration, satisfaction, efficiency, ...


Body Mass Index, Physical Activity, Sedentary Behavior, Sleep, and Gross Motor Skill Proficiency in Preschool Children From a Low- to Middle-Income Urban Setting

  • Published on June 9, 2019

Background Limited research reports on the relationship between body mass index (BMI) and physical activity (PA), sedentary behavior (SB), sleep, and gross motor skills (GMS) in low- and middle-income countries. The aim of this study was to (1) describe BMI, PA, SB, sleep duration, and GMS proficiency in South African preschool ...